The majority of women in the U.S. become infected with HIV as a result of:

The majority of women in the U.S. become infected with HIV primarily through male-to-female sexual contact. This route of transmission is significant because it reflects the patterns of sexual behavior and the epidemiology of HIV, particularly in the context of heterosexual relationships. Women are more likely to be infected during vaginal intercourse when exposed to an HIV-positive male partner due to various biological factors, such as the greater surface area of mucous membranes in the female genital tract compared to male counterparts, which increases susceptibility to the virus.

In contrast, other modes of transmission listed, such as IV drug use and blood transfusions, account for a smaller proportion of female HIV infections. While both of these routes do contribute to the overall incidence, they are less common compared to the impact of sexual contact. Male-to-female sexual contact clearly underscores the gendered dynamics of HIV transmission and illustrates the importance of focusing on sexual health and safe practices in addressing the epidemic among women.

Understanding this avenue of transmission helps inform public health strategies and education aimed at reducing the spread of HIV, emphasizing the need for protective measures during sexual activity and enhanced access to testing and healthcare services for women.